USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: NPM_HUMAN USC-OGP 2-DE database:  NPM_HUMAN NPM_HUMAN General information about the entry View entry in simple text format Entry name NPM_HUMAN Primary accession number P06748 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Nucleophosmin; Short=NPM; AltName: Full=Nucleolar phosphoprotein B23; AltName: Full=Nucleolar protein NO38; AltName: Full=Numatrin;. Gene name Name=NPM1 Synonyms=NPM Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1184: pI=5.92; Mw=43904 SPOT OGP-1207: pI=6.04; Mw=38036 Cross-references UniProtKB/Swiss-Prot P06748; NPM_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name NPM_HUMAN Primary accession number P06748 Secondary accession number(s) A8K3N7 B5BU00 D3DQL6 P08693 Q12826 Q13440 Q13441 Q14115 Q5EU94 Q5EU95 Q5EU96 Q5EU97 Q5EU98 Q5EU99 Q6V962 Q8WTW5 Q96AT6 Q96DC4 Q96EA5 Q9BYG9 Q9UDJ7 Sequence was last modified on  November 1, 1990 (version 2) Annotations were last modified on  March 15, 2017 (version 212) Name and origin of the protein Description RecName: Full=Nucleophosmin; Short=NPM; AltName: Full=Nucleolar phosphoprotein B23; AltName: Full=Nucleolar protein NO38; AltName: Full=Numatrin; Gene name Name=NPM1 Synonyms=NPM Encoded on Name=NPM1; Synonyms=NPM Keywords 3D-structure; Acetylation; ADP-ribosylation; Alternative splicing; Chaperone; Chromosomal rearrangement; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disulfide bond; Host-virus interaction; Isopeptide bond; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; RNA-binding; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M23613; AAA36380.1; -; mRNA EMBL M28699; AAA58386.1; -; mRNA EMBL M26697; AAA36385.1; -; mRNA EMBL U89321; AAB94739.1; -; Genomic_DNA EMBL U89309; AAB94739.1; JOINED; Genomic_DNA EMBL U89310; AAB94739.1; JOINED; Genomic_DNA EMBL U89311; AAB94739.1; JOINED; Genomic_DNA EMBL U89313; AAB94739.1; JOINED; Genomic_DNA EMBL U89314; AAB94739.1; JOINED; Genomic_DNA EMBL U89317; AAB94739.1; JOINED; Genomic_DNA EMBL U89319; AAB94739.1; JOINED; Genomic_DNA EMBL AB042278; BAB40600.1; -; mRNA EMBL AY740634; AAW67752.1; -; mRNA EMBL AY740635; AAW67753.1; -; mRNA EMBL AY740636; AAW67754.1; -; mRNA EMBL AY740637; AAW67755.1; -; mRNA EMBL AY740638; AAW67756.1; -; mRNA EMBL AY740639; AAW67757.1; -; mRNA EMBL AY740640; AAW67758.1; -; mRNA EMBL DQ303464; ABC40399.1; -; mRNA EMBL AY347529; AAQ24860.1; -; mRNA EMBL BT007011; AAP35657.1; -; mRNA EMBL AK290652; BAF83341.1; -; mRNA EMBL AB451236; BAG70050.1; -; mRNA EMBL AB451361; BAG70175.1; -; mRNA EMBL CH471062; EAW61443.1; -; Genomic_DNA EMBL CH471062; EAW61446.1; -; Genomic_DNA EMBL BC002398; AAH02398.1; -; mRNA EMBL BC008495; AAH08495.1; -; mRNA EMBL BC009623; AAH09623.1; -; mRNA EMBL BC012566; AAH12566.1; -; mRNA EMBL BC014349; AAH14349.1; -; mRNA EMBL BC016716; AAH16716.1; -; mRNA EMBL BC016768; AAH16768.1; -; mRNA EMBL BC016824; AAH16824.1; -; mRNA EMBL BC021668; AAH21668.1; -; mRNA EMBL BC021983; AAH21983.1; -; mRNA EMBL BC050628; AAH50628.1; -; mRNA EMBL BC107754; AAI07755.1; -; mRNA EMBL U41742; AAB00112.1; ALT_TERM; mRNA EMBL U41743; AAB00113.1; ALT_TERM; mRNA EMBL U04946; AAA58698.1; ALT_TERM; mRNA EMBL D45915; BAA08343.1; ALT_TERM; mRNA EMBL X16934; CAA34809.1; -; mRNA EMBL J02590; AAA36473.1; -; mRNA EMBL M31004; AAA36474.1; -; mRNA CCDS CCDS43399.1; -. [P06748-3]; . CCDS CCDS4376.1; -. [P06748-1]; . CCDS CCDS4377.1; -. [P06748-2]; . PIR A33423; A32915; . PIR I38491; I38491; . RefSeq NP_001032827.1; NM_001037738.2. [P06748-3]; . RefSeq NP_002511.1; NM_002520.6. [P06748-1]; . RefSeq NP_954654.1; NM_199185.3. [P06748-2]; . UniGene Hs.557550; -; . PDB 2LLH; NMR; -; A=225-294 PDB 2P1B; X-ray; 2.75 A; A/B/C/D/E/F/G/H/I/J=9-122 PDB 2VXD; NMR; -; A=243-294 PDB 5EHD; X-ray; 2.55 A; A/B/C/D/E/F/G/H/I/J/a/b/c/d/e/f/g/h/i/j=9-124 PDBsum 2LLH; -; . PDBsum 2P1B; -; . PDBsum 2VXD; -; . PDBsum 5EHD; -; . ProteinModelPortal P06748; -; . SMR P06748; -; . BioGrid 110929; 583; . DIP DIP-30932N; -; . IntAct P06748; 258; . MINT MINT-4938330; -; . STRING 9606.ENSP00000296930; -; . BindingDB P06748; -; . ChEMBL CHEMBL5178; -; . iPTMnet P06748; -; . PhosphoSitePlus P06748; -; . SwissPalm P06748; -; . BioMuta NPM1; -; . DMDM 114762; -; . DOSAC-COBS-2DPAGE P06748; -; . REPRODUCTION-2DPAGE IPI00549248; -; . SWISS-2DPAGE P06748; -; . EPD P06748; -; . MaxQB P06748; -; . PaxDb P06748; -; . PeptideAtlas P06748; -; . PRIDE P06748; -; . TopDownProteomics P06748-1; -. [P06748-1]; . TopDownProteomics P06748-2; -. [P06748-2]; . TopDownProteomics P06748-3; -. [P06748-3]; . DNASU 4869; -; . Ensembl ENST00000296930; ENSP00000296930; ENSG00000181163. [P06748-1]; . Ensembl ENST00000351986; ENSP00000341168; ENSG00000181163. [P06748-2]; . Ensembl ENST00000393820; ENSP00000377408; ENSG00000181163. [P06748-3]; . Ensembl ENST00000517671; ENSP00000428755; ENSG00000181163. [P06748-1]; . GeneID 4869; -; . KEGG hsa:4869; -; . UCSC uc003mbh.4; human. [P06748-1]; . CTD 4869; -; . DisGeNET 4869; -; . GeneCards NPM1; -; . HGNC HGNC:7910; NPM1; . HPA CAB012983; -; . HPA HPA011384; -; . MalaCards NPM1; -; . MIM 164040; gene; . neXtProt NX_P06748; -; . OpenTargets ENSG00000181163; -; . Orphanet 98834; Acute myeloblastic leukemia with maturation; . Orphanet 98833; Acute myeloblastic leukemia without maturation; . Orphanet 402026; Acute myeloid leukemia with NPM1 somatic mutations; . Orphanet 520; Acute promyelocytic leukemia; . PharmGKB PA31712; -; . eggNOG ENOG410IHZM; Eukaryota; . eggNOG ENOG4111IKX; LUCA; . GeneTree ENSGT00440000034554; -; . HOGENOM HOG000013061; -; . HOVERGEN HBG001860; -; . InParanoid P06748; -; . KO K11276; -; . OMA VEACICS; -; . OrthoDB EOG091G0NLY; -; . PhylomeDB P06748; -; . TreeFam TF327704; -; . Reactome R-HSA-180746; Nuclear import of Rev protein; . Reactome R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere; . Reactome R-HSA-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; . Reactome R-HSA-8869496; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; . SIGNOR P06748; -; . ChiTaRS NPM1; human; . EvolutionaryTrace P06748; -; . GeneWiki NPM1; -; . GenomeRNAi 4869; -; . PMAP-CutDB P06748; -; . PRO PR:P06748; -; . Proteomes UP000005640; Chromosome 5; . Bgee ENSG00000181163; -; . ExpressionAtlas P06748; baseline and differential; . Genevisible P06748; HS; . GO GO:0005813; C:centrosome; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0030529; C:intracellular ribonucleoprotein complex; IDA:MGI; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005730; C:nucleolus; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0031616; C:spindle pole centrosome; IDA:UniProtKB; . GO GO:0042393; F:histone binding; IDA:UniProtKB; . GO GO:0051059; F:NF-kappaB binding; IDA:UniProtKB; . GO GO:0046982; F:protein heterodimerization activity; IMP:UniProtKB; . GO GO:0042803; F:protein homodimerization activity; IDA:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0004860; F:protein kinase inhibitor activity; IDA:UniProtKB; . GO GO:0043023; F:ribosomal large subunit binding; IDA:MGI; . GO GO:0043024; F:ribosomal small subunit binding; IDA:MGI; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0030957; F:Tat protein binding; IDA:UniProtKB; . GO GO:0003713; F:transcription coactivator activity; IDA:UniProtKB; . GO GO:0051082; F:unfolded protein binding; IDA:UniProtKB; . GO GO:0007569; P:cell aging; IMP:UniProtKB; . GO GO:0034080; P:CENP-A containing nucleosome assembly; TAS:Reactome; . GO GO:0007098; P:centrosome cycle; IMP:UniProtKB; . GO GO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome GO GO:0006281; P:DNA repair; IDA:UniProtKB; . GO GO:0006886; P:intracellular protein transport; TAS:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB; . GO GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB; . GO GO:0010826; P:negative regulation of centrosome duplication; IMP:UniProtKB; . GO GO:0044387; P:negative regulation of protein kinase activity by regulation of protein phosphorylation; IDA:UniProtKB; . GO GO:0006913; P:nucleocytoplasmic transport; IDA:UniProtKB; . GO GO:0006334; P:nucleosome assembly; IDA:UniProtKB; . GO GO:1902751; P:positive regulation of cell cycle G2/M phase transition; IDA:UniProtKB; . GO GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB; . GO GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB; . GO GO:0045893; P:positive regulation of transcription; DNA-templated; IDA:UniProtKB GO GO:0045727; P:positive regulation of translation; IDA:UniProtKB; . GO GO:0008104; P:protein localization; IDA:UniProtKB; . GO GO:0051259; P:protein oligomerization; IDA:MGI; . GO GO:0046599; P:regulation of centriole replication; IMP:UniProtKB; . GO GO:0060735; P:regulation of eIF2 alpha phosphorylation by dsRNA; IDA:UniProtKB; . GO GO:0032071; P:regulation of endodeoxyribonuclease activity; IDA:UniProtKB; . GO GO:0060699; P:regulation of endoribonuclease activity; IDA:UniProtKB; . GO GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:Reactome; . GO GO:0006950; P:response to stress; IMP:UniProtKB; . GO GO:0042255; P:ribosome assembly; TAS:UniProtKB; . GO GO:0007165; P:signal transduction; NAS:UniProtKB; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 2.60.120.340; -; 1; . InterPro IPR032569; NPM1_C; . InterPro IPR004301; Nucleoplasmin; . InterPro IPR024057; Nucleoplasmin_core_dom; . PANTHER PTHR22747; PTHR22747; 1; . Pfam PF16276; NPM1-C; 1; . Pfam PF03066; Nucleoplasmin; 1; . SUPFAM SSF69203; SSF69203; 1; .

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